You can play with friends or strangers, and it’s a good way to practice if playing competitively is your style-but of course it rather lacks the human element that makes the game so much fun IRL. The interface is best paired with a mouse and keyboard, but does work on most phones or tablets as well. Probably the easiest way to play from home is Pretend You’re Xyzzy, a web version of the game with all major (and quite a few minor) expansions. *You can get an idea for the game here, but be warned it’s largely NSFW.
Playing with tree carcasses is so last century, so let’s look at some cheaper and more convenient high tech alternatives.
Using the real cards is probably the nicest way to play, but these cards cost quite a bit - £72 for the base game and all the major expansions, and more if you get additional, smaller expansions or a box big enough to keep them all in. You can print out the game yourself (it’s available for free online), or order professionally made card packs from the creators. Cards Against Humanity is a fun, crass fill-in-the-blank party game, played using a set of question cards and answer cards*.